Supreme Court to hear “pay-for-delay” drug case












(Reuters) – The Supreme Court on Friday agreed to decide whether brand-name drug companies may pay money to generic drug rivals to keep their lower-priced products off the market, a practice estimated to cost consumers and the government billions of dollars each year.


The arrangements, known as “pay-for-delay” or “reverse payments,” have for more than a decade vexed antitrust enforcers including the Federal Trade Commission, which have been stung until recently by a series of court decisions allowing such practices.












In a typical case, a generic rival challenges the patent of a brand-name competitor, which then pays the rival a sum of money to drop its challenge. Defenders of the practice call it a legitimate means to resolve patent litigation.


The court accepted an appeal by the FTC, which had challenged annual payments of $ 31 million to $ 42 million by Solvay Pharmaceuticals Inc, now owned by Abbott Laboratories Inc, to stop generic versions of AndroGel, a treatment for the underproduction of testosterone, until 2015.


These payments went to such rivals as Watson Pharmaceuticals Inc, Paddock Laboratories Inc and Par Pharmaceutical Cos, and were intended to help Solvay preserve annual profits estimated at $ 125 million. The 11th U.S. Circuit Court of Appeals in Atlanta upheld the arrangement in April.


(Reporting by Jonathan Stempel in New York; Editing by Kevin Drawbaugh)


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Employment ducks superstorm Sandy punch












WASHINGTON (Reuters) – Companies kept up their steady but slow hiring pace in November, defying predictions that superstorm Sandy would deal a big blow to the labor market.


While the unemployment rate fell to a near four-year low of 7.7 percent, that was only because many Americans gave up the hunt for work, tempering the signal from the stronger-than-expected payrolls growth.












A big drop in consumer confidence in December also offered a cautionary note on the economy’s health.


Nonfarm employment expanded by 146,000 jobs last month after gaining 138,000 in October, the Labor Department said on Friday. The increase was well above the 93,000 expected on Wall Street.


“We are moving in a trend-like modest job-growth environment,” said Michael Hanson, a senior economist at Bank of Bank of America Merrill Lynch in New York. “We really need to see payroll numbers break above 200,000 for a while to think we have a more sustained recovery underway.”


The government said Sandy, which slammed the densely populated East Coast in late October, did not have a substantive impact on the data. Economists had thought it would, with some predicting it would cut up to 75,000 jobs off payrolls growth.


Nevertheless, the storm did hit the economy hard.


Sandy knocked retail sales and industrial output in October and led to a big spike in claims for jobless benefits, one of the reasons economists expected job growth to slow.


A Labor Department survey of households found 369,000 workers were unable to make it to work in the aftermath of the storm and a further 1.1 million ended up working only part time. However, the department still considered them employed.


U.S. stocks were little changed at mid-day, with the downbeat reading on consumer confidence largely offsetting the stronger-than-expected payrolls data. Prices for U.S. government debt fell, while the dollar edged up against a basket of currencies.


MODEST TREND


November’s job gains left them just below the monthly average of 151,000 that has prevailed since January.


Economists consider that pace just enough to push the jobless rate lower over time. But they say roughly 200,000 to 250,000 jobs per month would be needed to make noticeable headway in absorbing the 22.7 million Americans who are either jobless or underemployed.


The 0.2 percentage point drop in the unemployment rate, which took it to its lowest level since December 2008, was due to a decrease in the size of the labor force, a suggestion frustrated Americans were giving up the hunt for work.


The labor force participation rate, or the proportion of working-age Americans who have a job or are looking for one, fell back to near a 31-year low.


Heidi Shierholz, an economist at the Economic Policy Institute in Washington, said it could take more than 10 years for the unemployment rate to drop back to its pre-recession level around 5 percent at the current pace of job growth.


Last month, the retail sector accounted for more than a third of jobs gains, which economists tied to a brisk start to the holiday shopping season. Still, private hiring slowed to 147,000 from 189,000 in October, pulled down by a sharp decline in construction employment and weak manufacturing payrolls.


FISCAL CLIFF WORRIES


Employment continues to be held back by fears the government may fail to prevent the $ 600 billion in automatic tax hikes and government spending cuts set to take hold at the start of next year. The debt crisis in Europe has also weighed.


Worries about this so-called fiscal cliff hit consumer sentiment in early December. The Thomson Reuters/University of Michigan’s preliminary confidence reading plummeted to 74.5 from 82.7 in November.


“That confirms my belief that the only thing the economy has to fear is Washington itself,” said Joel Naroff, chief economist at Naroff Economic Advisors in Holland, Pennsylvania.


“There is some real underlying strength in the economy as the November jobs numbers indicate, but it could be wiped out by the games being played by our political representatives,” he said.


With the labor market far from full health, Federal Reserve policymakers, who meet on Tuesday and Wednesday, look certain to keep U.S. monetary policy on its current ultra-easy course.


Economists said an anticipated tightening of fiscal policy next year, even if a deal is reached to avoid completely going over the fiscal cliff, provides ample reason for the U.S. central bank to maintain its stance.


The retail sector added 52,600 jobs last month after rising 50,900 in October. The pace of retail hiring over the last three months was the fastest since 1995.


There were also increases in information and temporary help hiring. But transport, financial, education and health services employment slowed.


Manufacturing employment fell 7,000, marking the third month it has dropped this year.


Construction payrolls surprisingly tumbled 20,000, despite a surge in homebuilding, which is benefiting from the Fed’s effort to hold borrowing costs down. Economists said they expect construction jobs to rise in the coming months as the housing recovery returns full swing.


Average hourly earnings increased four cents. In the 12 months to November, average hourly earnings are up just 1.7 percent, underscoring the trouble workers are having keeping up with inflation.


(Additional reporting by Richard Leong in New York; Editing by Andrea Ricci, Tim Ahmann and James Dalgleish)


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Protesters surge around Egypt’s presidential palace












CAIRO (Reuters) – Tens of thousands of Egyptian protesters surged around the presidential palace on Friday and the opposition rejected President Mohamed Mursi‘s call for dialogue to end a crisis that has polarized the nation and sparked deadly clashes.


The Islamist leader’s deputy said he could delay a December 15 referendum on a constitution that liberals opposed, although the concession only partly meets a list of opposition demands that include scrapping a decree that expanded Mursi‘s powers.












“The people want the downfall of the regime” and “Leave, leave,” crowds chanted after bursting through barbed wire barricades and climbing on tanks guarding the palace of Egypt‘s first freely elected president.


Their slogans echoed those used in a popular revolt that toppled Mursi’s predecessor Hosni Mubarak in February 2011.


Vice President Mahmoud Mekky said in a statement sent to local media that the president was prepared to postpone the referendum if that could be done without legal challenge.


The dialogue meeting was expected to go ahead on Saturday in the absence of most opposition factions. “Tomorrow everything will be on the table,” a presidential source said of the talks.


The opposition has demanded that Mursi rescind a November 22 decree giving himself wide powers and delay the vote set for December 15 on a constitution drafted by an Islamist-led assembly which they say fails to meet the aspirations of all Egyptians.


The state news agency reported that the election committee had postponed the start of voting for Egyptians abroad until Wednesday, instead of Saturday as planned. It did not say whether this would affect the timing of voting in Egypt.


Ahmed Said, leader of the liberal Free Egyptians Party, told Reuters that delaying expatriate voting was made to seem like a concession but would not change the opposition’s stance.


He said the core opposition demand was to freeze Mursi’s decree and “to reconsider the formation and structure of the constituent assembly”, not simply to postpone the referendum.


The opposition organized marches converging on the palace which elite Republican Guard units had ringed with tanks and barbed wire on Thursday after violence between supporters and opponents of Mursi killed seven people and wounded 350.


Islamists, who had obeyed a military order for demonstrators to leave the palace environs, held funerals on Friday at Cairo’s al-Azhar mosque for six Mursi partisans who were among the dead. “With our blood and souls, we sacrifice to Islam,” they chanted.


“ARM-TWISTING”


In a speech late on Thursday, Mursi had refused to retract his November 22 decree or cancel the referendum on the constitution, but offered talks on the way forward after the referendum.


The National Salvation Front, the main opposition coalition, said it would not join the dialogue. The Front’s coordinator, Mohamed ElBaradei, a Nobel peace laureate, dismissed the offer as “arm-twisting and imposition of a fait accompli”.


Murad Ali, spokesman of the Brotherhood’s Freedom and Justice Party (FJP), said opposition reactions were sad: “What exit to this crisis do they have other than dialogue?” he asked.


Mursi’s decree giving himself extra powers sparked the worst political crisis since he took office in June and set off renewed unrest that is dimming Egypt’s hopes of stability and economic recovery after nearly two years of turmoil following the overthrow of Mubarak, a military-backed strongman.


The turmoil has exposed contrasting visions for Egypt, one held by Islamists, who were suppressed for decades by the army, and another by their rivals, who fear religious conservatives want to squeeze out other voices and restrict social freedoms.


Caught in the middle are many of Egypt’s 83 million people who are desperate for an end to political turbulence threatening their precarious livelihoods in an economy under severe strain.


“We are so tired, by God,” said Mohamed Ali, a laborer. “I did not vote for Mursi nor anyone else. I only care about bringing food to my family, but I haven’t had work for a week.”


ECONOMIC PAIN


A long political standoff will make it harder for Mursi’s government to tackle the crushing budget deficit and stave off a balance of payments crisis. Austerity measures, especially cuts in costly fuel subsidies, seem inevitable to meet the terms of a $ 4.8-billion IMF loan that Egypt hopes to clinch this month.


U.S. President Barack Obama told Mursi on Thursday of his “deep concern” about casualties in this week’s clashes and said “dialogue should occur without preconditions”.


The upheaval in the most populous Arab nation worries the United States, which has given billions of dollars in military and other aid since Egypt made peace with Israel in 1979.


The conflict between Islamists and opponents who each believe the other is twisting the democratic rules to thwart them has poisoned the political atmosphere in Egypt.


The Muslim Brotherhood’s spokesman, Mahmoud Ghozlan, told Reuters that if the opposition shunned the dialogue “it shows that their intention is to remove Mursi from the presidency and not to cancel the decree or the constitution as they claim”.


Ayman Mohamed, 29, a protester at the palace, said Mursi should scrap the draft constitution and heed popular demands.


“He is the president of the republic. He can’t just work for the Muslim Brotherhood,” Mohamed said of the eight-decade-old Islamist movement that propelled Mursi from obscurity to power.


(Additional reporting by Omar Fahmy; Writing by Edmund Blair and Alistair Lyon; Editing by Giles Elgood)


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Facebook might buy Microsoft’s Atlas Ad platform to compete with Google












Is Facebook (FB) preparing to compete with Google (GOOG) in online advertising? According to AllThingsD and BusinessInsider’s sources Facebook might be taking steps to build its own advertising network for online websites. AllThingsD says that rather than build a new advertising network from scratch, Facebook could just buy Microsoft’s (MSFT) Atlas Solutions platform “that already delivers billions of ad impressions a day.”


BusinessInsider reports that Facebook will reportedly pay a lower price than the $ 6 billion that Microsoft paid for aQuantive in 2007 that included Atlas Solutions. It’s estimated that Atlas is worth more than $ 30 million — a small price to pay to compete with Google’s DoubleClick ad network.












So why is Facebook interested in advertising now? Well, it’s got over 1 billion active users with emails, phone numbers, and unprecedented amounts of “likes.” As BusinessInsider puts itFacebook has so much data it could “tell marketers whether or not a Facebook user saw, on Facebook.com, an ad for a product before going to the store and buying it.”


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Kristen Wiig may join “Anchorman: The Legend Continues”












LOS ANGELES (TheWrap.com) – Kristen Wiig is being eyed for a role in “Anchorman: The Legend Continues” for Paramount Pictures, a person familiar with the negotiations has told TheWrap.


Wiig would play opposite Steve Carell, as a love interest in the sequel. The script is still being written, and no cast beyond the principals has been set.












Adam McKay is directing the feature, which is being produced by Judd Apatow through his Apatow Productions banner. The film is a sequel to the 2004 hit, “Anchorman: The Legend of Ron Burgundy” and is due to be released in October 2013.


Best known for her work on “Saturday Night Live,” Wiig is one of the most in-demand actresses in Hollywood, since appearing in the film “Bridesmaids.” She could recently be seen at the Toronto International Film Festival in the indie feature “Imogene,” and has been busy filming a number of titles, including “The Secret Life of Walter Mitty,” and “Hateship Friendship,” with Guy Pearce.


“Anchorman: The Legend Continues” will see the original film’s cast return, including Will Ferrell, Christina Applegate, Paul Rudd and Carell. The story follows the on-set adventures of San Diego’s top newsman who is played by Ferrell. “Anchorman: The Legend of Ron Burgundy” made around $ 85 million at the box office.


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Why are People so Interested in the DSM-5?












There is a lot of internet buzz about the approval by the American Psychiatric Association‘s (APA) board of trustees of its fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5.)


The APA press release notes “the trustees’ action marks the end of the manual’s comprehensive revision process, which has spanned over a decade and included contributions from more than 1,500 experts in psychiatry, psychology, social work, psychiatric nursing, pediatrics, neurology, and other related fields from 39 countries.”The approval was announced on Saturday, December 1 (was the APA trying to keep it quiet?) with publication of the DSM-5 scheduled spring 2013. For a book that has no plot or characters, its pending publication has caused great excitement. True, it is a sequel, but it is not the latest installment of Harry Potter or the Twilight Saga.Though the DSMs have not reached the volume of sales of a Harry Potter (so far), the paperback edition of the last version of the DSM had a sales rank of 261 on Amazon.com. This is remarkable for a book that is over 900 pages in length and written for professionals.Besides being bestsellers, the DSMs have inspired games and even music awards. DSM-IV the Game is available for free online. It is described as “beautiful way to engage and learn about yourself, family, and friends and as an ice breaker at your next holiday gathering.”Several years ago, Dr. Jill Squyres, a clinical psychologist in San Antonio, created the DSM-IV Music Awards for her professional society’s fall social. The DSM-IV Music Awards are modeled on the Academy Awards. She chooses categories based on a DSM diagnosis and then nominates songs that are reflective of disorders such as Major Depression (Jagged Little Pill by Alanis Morisette, King of Pain by the Police), Mania (Wake Me Up Before You Go Go by Wham, Life in the Fast Lane by the Eagles), Obsessive-Compulsive Disorder (I’m In Love With My Car by Queen, Pinball Wizard by the Who), and Borderline Personality Disorder (Isn’t life Strange by Jim Morrison, Addicted to Love by Robert Palmer).How does a medical book about psychiatric disorders inspire games and awards let alone become a bestseller? There are not enough medical professionals or people with vested interests, such as the pharmaceutical or insurance industries, to account for these sales figures. What is behind the fascination with the DSM among the general public? I believe it is because our mental state goes to the core of who we are as human beings and our fascination with the link between mental illness and creativity.Mental illness went “public” long before cancer and AIDS. Although mental illness is still considered a stigma by the general public, writers and artists have been talking publicly about their bouts of depression and struggles with alcohol and drugs for hundreds of years. Ernest Hemingway, Virginia Woolf, Sylvia Path and Vincent van Gogh committed suicide. The poets T.S. Eliot and Ezra Pound were committed to mental institutions. The 27 club is comprised of musicians who died at age 27; Janis Joplin, Jimi Hendrix, Brian Jones, Kurt Cobain, and Amy Winehouse. The public breakdowns and rants of Mel Gibson, Alec Baldwin, Lindsay Lohan, Charlie Sheen and Mel Gibson have been televised and viewed by millions on YouTube.The style and language of the DSM is another reason for its popularity. Unlike most medical textbooks , there is relatively little medical terminology and diagnoses are described in terms that are easily understandable to the nonmedical reader. Each diagnosis includes a list of symptoms, referred to as criteria, that typify the disorder. The list of symptoms is exhaustive, but not all symptoms necessarily occur in the disorder. The format and clear non-technical language invite the reader to examine and apply this new knowledge to themselves and others. A parent who worries that his child might have Attention Deficit Hyperactivity Disorder (ADHD) or a spouse concerned that their loved one is displaying symptoms of Alzheimer’s disease can easily look up these disorders and review the symptom check list.Psychiatric disorders consist of behaviors that are extreme. The same behaviors occur with less intensity or frequency in everyday living. A key symptom of Major Depression Disorder is anhedonia, a failure to find pleasure in everyday life. Anhedonia was the working title of Woody Allen’s movie Annie Hall, which won four Academy Awards including Best Picture. In mild or moderate degrees, most of us have experienced “mild anhedonia” (a.k.a being in a funk) at some point in our lives.Obsessive-compulsive disorder (OCD) is an anxiety disorder marked by obsessions, which consist of unwanted and repeated thoughts, or behaviors, and compulsions that make those with OCD feel compelled to perform a behavior to lessen their anxiety. Although most of us are not paralyzed by OCD, we all have some traits. We go back and check to see if we locked our doors or left the tea kettle on. And although we might wish to have the detective skills of Adrian Monk or the writing skills of Jack Nicholson in As Good As It Gets , these fictional characters inability to cope with OCD causes them great anguish and the inability to have significant relationships.I believe that today’s films and TV shows that portray mental illness are popular because they present characters we can relate to, unlike earlier films such as Psycho, a film that scared people so much they stopped taking showers. We laugh at the neurotic mother-son relationships portrayed in Everyone Loves Raymond and Seinfeld because we can relate to them. And we worry about our children. Are we pushing them so hard that they will end up like Natalie Portman’s crazed ballerina in the Black Swan?Brain scans have shown that that creativity and “madness” light up similar pathways in the brain. However, the overwhelming majority of mentally ill people are not artists and most artists are not mentally ill. Edgar Allen Poe, Vincent Van Gogh and Ernest Hemingway were gifted artists who happened to be mentally ill. Their mental illness did not make them artists. In fact, mental illness interferes with the artistic process. William Styron was not able to write in the throes of his depression. The mathematician John Nash did his greatest work before he was diagnosed with schizophrenia.I have no doubt that some gifted people are able to function by “throwing themselves into their art.” However, their legacy is their work, not their mental illness. People may fantasize about being able to play guitar like Jimi Hendrix, write like Hemingway, and sing and dance like Michael Jackson. But they don’t fantasize about being clinically depressed, overdosing on drugs, being homeless, or being institutionalized.To answer to my question of why we are so fascinated by the DSM, I believe it is because it presents and explains extremes of behavior, related to and connected with the more normal levels of behavior we experience. We read the DSM to find ourselves in its pages.Images: Vincent Van Gogh; Janis Joplin; MONK cover by author.












Follow Scientific American on Twitter @SciAm and @SciamBlogs.Visit ScientificAmerican.com for the latest in science, health and technology news.
© 2012 ScientificAmerican.com. All rights reserved.
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Intel CEO Otellini expects insider to replace him












SAN FRANCISCO (Reuters) – Intel‘s outgoing chief executive, Paul Otellini, said he expected to be replaced by a company insider and also signaled that the top chipmaker could open its factories to strategic customers.


Otellini’s comments at a Sanford Bernstein investor conference on Wednesday stoked speculation the top chipmaker may manufacture mobile chips for Apple and pushed Intel’s shares higher on Thursday morning.












“For the right types of products and not to enable my competitors, I would certainly consider it. There’s a lot of stuff in the pipeline,” Otellini said, according to a Thomson One transcript.


“As you know it takes a while to move your designs over, to design them under our process, for us to be able to bring them in-house and so forth and our foundry customers aren’t going to announce that they’ve moved until they’ve moved because it would hurt them at their current suppliers, Otellini said.


RBC analyst Doug Freedman said Otellini’s comments about the possibility of open Intel’s plants to customers were more direct than previous ones.


Apple currently depends on Samsung Electronics to manufacture its mobile chips but the two companies are in a war over patents and also compete in smarpthones and tablets. Apple is believed to be looking for alternative suppliers.


Intel raised eyebrows on Wall Street and in Silicon Valley in November when it said it will consider an outsider to take over after Otellini unexpectedly announced he will retire in May, potentially ending a four-decade tradition of internal succession.


Some analysts took that as a sign that Intel, which has struggled to jump from the personal computer market to mobile, might be considering a transformative hire. But Otellini he expects the board to choose from among the chipmaker’s own executives.


“It’s not up to me but I think that’s the most likely outcome. I’m very comfortable with the internal candidates and the track record of internal versus external in our industry shows pretty clearly you want to stay inside if you can,” Otellini said.


While the idea of an iconic visionary stepping in to lift Intel into the mobile market – its Achilles heel – may sound attractive, it could open the chipmaker to new risks should it waver from its traditional focus on hard-core manufacturing.


“Even if you brought in Mr. or Ms. Perfect, that person is going to take whatever it is, two years to figure out the culture and the people and how systems work and stuff like that,” Otellini said.


“In this environment, why take the risk and take the time? So I think they will stay inside.”


Shares of Intel rose 1.66 percent to $ 20.17.


(Reporting By Noel Randewich; Editing by M.D. Golan)


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Toronto mayor to stay in power pending appeal of ouster












TORONTO (Reuters) – Toronto Mayor Rob Ford can stay in power pending an appeal of a conflict of interest ruling that ordered him out of his job as leader of Canada’s biggest city, a court ruled on Wednesday.


Madam Justice Gladys Pardu of the Ontario Divisional Court suspended a previous court ruling that said Ford should be ousted. Ford’s appeal of that ruling is set to be heard on January 7, but a decision on the appeal could take months.












Justice Pardu stressed that if she had not suspended the ruling, Ford would have been out of office by next week. “Significant uncertainty would result and needless expenses may be incurred if a by-election is called,” she said.


If Ford wins his appeal, he will get to keep his job until his term ends at the end of 2014. If he loses, the city council will either appoint a successor or call a special election, in which Ford is likely to run again.


“I can’t wait for the appeal, and I’m going to carry on doing what the people elected me to do,” Ford told reporters at City Hall following the decision.


Ford, a larger-than-life character who took power on a promise to “stop the gravy train” at City Hall, has argued that he did nothing wrong when he voted to overturn an order that he repay money that lobbyists had given to a charity he runs.


Superior Court Justice Charles Hackland disagreed, ruling last week that Ford acted with “willful blindness” in the case, and must leave office by December 10.


Ford was elected mayor in a landslide in 2010, but slashing costs without cutting services proved harder than he expected, and his popularity has fallen steeply.


He grabbed unwelcome headlines for reading while driving on a city expressway, for calling the police when a comedian tried to film part of a popular TV show outside his home, and after reports that city resources were used to help administer the high-school football team he coaches.


The conflict-of-interest drama began in 2010 when Ford, then a city councillor, used government letterhead to solicit donations for the football charity created in his name for underprivileged children.


Toronto’s integrity commissioner ordered Ford to repay the C$ 3,150 ($ 3,173) the charity received from lobbyists and companies that do business with the city.


Ford refused to repay the money, and in February 2012 he took part in a city council debate on the matter and then voted to remove the sanctions against him – despite being warned by the council speaker that voting would break the rules.


He pleaded not guilty in September, stating that he believed there was no conflict of interest as there was no financial benefit for the city. The judge dismissed that argument.


In a rare apology after last week’s court ruling, he said the matter began “because I love to help kids play football”.


Ford faces separate charges in a C$ 6 million libel case about remarks he made about corruption at City Hall, and is being audited for his campaign finances. The penalty in the audit case could also include removal from office.


(Reporting by Claire Sibonney; Editing by Janet Guttsman, Russ Blinch, Nick Zieminski; and Peter Galloway)


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25 top-rated Facebook games from 2012












Games can be both a welcome and an annoying diversion on Facebook, the world’s most popular online social network. This year, Facebook crossed a big milestone — reaching 1 billion active users. Game companies such as “FarmVille” creator Zynga Inc. and Rovio Entertainment Ltd. of “Angry Birds” fame seek to tap into that vast base of users to gain more players for their games.


This week, Facebook Inc. issued a list of the 25 top-rated games that launched on Facebook in 2012. The company says the rankings are based on user ratings and engagement with the games. It’s the same methodology that Facebook uses to rank apps in its App Center.












Some of the games are played on Facebook’s website, while others are only on Apple Inc.‘s iOS or Google Inc.‘s Android devices using Facebook’s app.


Here’s the list:


1. “SongPop” (by FreshPlanet, on Facebook.com, iOS and Android)


2. “Dragon City” (by Social Point, on Facebook.com)


3. “Bike Race” (by Top Free Games, on iOS)


4. “Subway Surfers” (by Kiloo, on iOS and Android)


5. “Angry Birds Friends (by Rovio, on Facebook.com)


6. “FarmVille 2″ (by Zynga, on Facebook.com)


7. “Scramble with Friends” (by Zynga, on iOS)


8. “Clash of Clans” (by Supercell, on iOS)


9. “Marvel: Avengers Alliance” (by Playdom, on Facebook.com)


10. “Draw Something” (by Zynga, on iOS and Android)


11. “Hay Day” (by Supercell, on iOS)


12. “Baseball Heroes” (by Syntasia, on Facebook.com)


13. “ChefVille” (by Zynga, on Facebook.com)


14. “CSR Racing” (by NaturalMotion Games, on iOS)


15. “Candy Crush Saga” (by King.com, on Facebook.com and iOS)


16. “Matching With Friends” (by Zynga, on Facebook.com)


17. “Legend Online” (by Oasis Games, on Facebook.com)


18. “Jurassic Park Builder” (by Ludia, on Facebook.com)


19. “Dungeon Rampage” (by Rebel Entertainment, on Facebook.com)


20. “Pockie Ninja II Social” (by NGames Ltd., on Facebook.com)


21. “Jetpack Joyride” (by Halfbrick, on Facebook.com)


22. “Social Empires” (by Social Point, on Facebook.com and iOS)


23. “Bil ve Fethet” (by Peak Games, on Facebook.com)


24. “Ruby Blast Adventures” (by Zynga, on Facebook.com and iOS)


25. “Pyramid Solitaire Saga” (by King.com, on Facebook.com)


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Asthma symptoms may vary during menstrual cycle












NEW YORK (Reuters Health) – Some women may have more or fewer asthma symptoms, such as coughing and wheezing, depending on their time of the month, a new study suggests.


Researchers said spikes and dips in estrogen and other hormones likely affect the lungs and other physiological responses involved in breathing. However, it’s still unclear whether the findings could improve doctors’ treatment of women with asthma.












The menstrual cycle “is a very important cycle… with all the biological changes and physiological things that happen,” said Dr. Samar Farha from the Cleveland Clinic, who studies asthma and other respiratory diseases but wasn’t involved in the new research.


“(Some) asthmatics describe that just before their menses, they get a worsening of their symptoms,” she told Reuters Health – but more scientific assessments of what’s going on have come to conflicting conclusions.


For the new study, researchers surveyed close to 4,000 women in Northern Europe who had normal periods and weren’t taking birth control pills.


Along with other health and lifestyle questions, they asked women to report when their last period started, as well as whether they’d had any breathing-related problems in the past three days – such as wheezing or waking up with a coughing attack.


Just under eight percent of women in the study had been diagnosed with asthma. Between two and six percent reported recent wheezing, coughing and/or shortness of breath.


Dr. Ferenc Macsali of Haukeland University Hospital in Bergen, Norway, and colleagues found the number of women with of each of those symptoms changed depending on where they were in their menstrual cycle.


For example, wheezing spiked just before and just after mid-cycle (ovulation). The dip in between corresponds to peaks in estrogen, follicle stimulating hormone and luteinizing hormone, the researchers write in the American Journal of Respiratory and Critical Care Medicine.


Complaints of shortness of breath and coughing both declined just after women got their periods, and shortness of breath was also more rare right before menses started.


Macsali’s team saw cyclical patterns in breathing symptoms in women with and without asthma.


What explains those patterns is still up for debate. Estrogen may affect the lungs directly, the researchers said. Insulin resistance and markers of general inflammation are known to vary during the menstrual cycle, which could also play a role in when breathing symptoms get better or worse.


“The observed patterns in our study are most likely a result of… complex hormonal processes,” the researchers wrote, “and it does not seem plausible that one sex hormone should explain the variation in respiratory symptoms during the menstrual cycle.”


Women with asthma should “be aware of a possibility that their symptoms are influenced by day in cycle,” Macsali told Reuters Health in an email.


Not all asthmatics will notice those changes, Farha pointed out.


For women whose symptoms do get a little worse at certain times of the month, it’s also unclear whether that ever puts them in serious danger, she added. But Farha said it may still be worth bringing up the issue with their doctor.


“It could lead to more personalized therapy, based on where their symptoms are getting worse, in which phases of their menstrual cycle,” Farha said. “You could change therapy and escalate therapy based on (those) phases.”


SOURCE: http://bit.ly/SGe7b0 American Journal of Respiratory and Critical Care Medicine, online November 29, 2012.


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