Cialis impotence drug helps muscular dystrophy patients












LONDON (Reuters) – Eli Lilly‘s erectile dysfunction drug Cialis can correct abnormal blood flow in patients with a certain type of muscular dystrophy and could in future be used to slow progression of the disorder, researchers said on Wednesday.


The findings suggest that while Cialis can’t cure the condition, known as Becker muscular dystrophy, it could be used as a treatment to slow or prevent muscle weakening and help patients retain more function for longer.












Becker muscular dystrophy (BMD) is an inherited disorder that involves slowly worsening muscle weakness of the legs and pelvis. It is mostly found in boys and occurs in about 3 to 6 out of every 100,000 births.


Patients with BMD often have difficulties with walking that get worse over time. There is no cure for the condition, and by the age of 25 to 30 many patients are unable to walk.


In a small study involving men with the disorder, researchers from the Cedars-Sinai Medical Center, Los Angeles, in the United States took measurements when volunteers’ forearm muscles were either rested or lightly exercised with a handgrip.


They found that almost all the patients had defective blood flow when they exercised. This lack of blood flow may contribute to muscle fatigue and weakness, the researchers wrote in a study in the journal Science Translational Medicine.


But after giving some of the patients a single oral dose of Cialis and comparing them to others given a placebo, or dummy pill, the scientists found that normal blood flow was restored to the muscles of 8 out of 9 patients who got the drug.


Like other erectile dysfunction drugs, Cialis, known generically as tadalafil, dilates blood vessels and is designed to increase blood flow. In the impotence drug market, it is a longer-acting alternative to Pfizer’s blue pill, Viagra.


Sales of Cialis for erectile dysfunction brought in $ 1.875 billion for Eli Lilly in 2011, up 10 percent on 2010.


While using the drug in BMD may be a possibility in future, the researchers cautioned that doctors should not prescribe it for this indication until more, larger studies have been conducted to show whether the improved blood flow has a meaningful effect on dystrophic muscles.


(Reporting by Kate Kelland; Editing by Louise Heavens)


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Tunisia secures more loans as protests hit deprived town












TUNIS (Reuters) – Tunisia, struggling to ease economic difficulties that have provoked unrest since its democratic revolution, said on Wednesday it had secured more international lending to cover its 2013 spending.


Tunisia’s new, elected Islamist-led government has sought to revive the economy in the face of a decline in trade with the crisis-hit euro zone and disputes between secularists and hardline Salafi Islamists over the future direction of the North African Arab state.












At least 200 people were injured when Tunisians demanding jobs clashed with police on Tuesday and Wednesday in the city of Siliana in a region on the edge of the Sahara desert that has long complained of economic deprivation.


The state news agency TAP said Tunis had clinched a $ 500 million loan from the African Development Bank, after the World Bank approved a $ 500 million loan on Tuesday, and a government minister told Reuters finances were now in order for 2013.


“Next year our public expenditure is essentially covered, thanks also to lines of credit for a total of $ 1 billion from the World Bank and the African Development Bank,” Investment Minister Riad Bettaieb said on the sidelines of a meeting with a European Union business delegation.


“So we are not planning to ask for further international support from the International Monetary Fund (IMF),” he said.


But he said Tunisia could ask the IMF for a standby credit line worth $ 2.5 billion for 2014 and beyond. “We are considering asking the IMF for a precautionary line of credit to give a guarantee for our financing needs … around $ 2.5 billion.”


The loans, the World Bank’s second since the “Arab Spring” uprising that toppled autocrat Zain al-Abidine Ben Ali in January 2011, aim to support economic recovery by improving the business and financial sectors and reforming social services.


BLINDED BY BIRDSHOT


In Siliana on Wednesday, police fired tear gas and rubber bullets to disperse crowds who rallied for a second day.


A medic from Siliana Hospital who did not wish to named said more than 200 people had been injured in the clashes. A journalist from France 24 television told Reuters he and a colleague had been hospitalized for wounds from birdshot apparently fired by riot police.


State media said 17 people had been blinded by birdshot wounds to the eyes. Residents blocked the entrances to the city, setting tyres alight on roads.


Many protesters called for the resignation of local officials, saying the authorities had failed to release development funds for their region.


Iyed Dahmani, a politician from the Republican Party in the town, said the national guard – an interior ministry-run security force – had deployed tanks to help restore order.


Interior Minister Ali Larayed appeared on state television to call for calm. “I ask people in Siliana to calm down, to protest calmly and accept dialogue,” he said, accusing leftist politicians of inflaming the situation.


But state TV also showed Prime Minister Hamadi Jebali saying he would not remove the unpopular governor of the region: “I won’t accept sacking him; he will stay in place.”


Jebali has accused both Salafis and liberal elites of harming Tunisia’s economy and image through their conflict with each other. His Ennahda party has tried to present itself as a middle way between liberals and Salafis.


The protests are the fiercest since hardline Salafi Islamists attacked the U.S. embassy in Tunis in September over an anti-Islam film made in California. That violence left four people dead.


(Writing by Andrew Hammond)


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Rapper PSY wants Tom Cruise to go ‘Gangnam Style’












BANGKOK (AP) — The South Korean rapper behind YouTube’s most-viewed video ever has set what might be a “Mission: Impossible” for himself.


Asked which celebrity he would like to see go “Gangnam Style,” the singer PSY told The Associated Press: “Tom Cruise!”












Surrounded by screaming fans, he then chuckled at the idea of the American movie star doing his now famous horse-riding dance.


PSY’s comments Wednesday in Bangkok were his first public remarks since his viral smash video — with 838 million views — surpassed Justin Bieber‘s “Baby,” which until Saturday held the record with 803 million views.


“It’s amazing,” PSY told a news conference, saying he never set out to become an international star. “I made this video just for Korea, actually. And when I released this song — wow.”


The video has spawned hundreds of parodies and tribute videos and earned him a spotlight alongside a variety of superstars.


Earlier this month, Madonna invited PSY onstage and they danced to his song at one of her New York City concerts. MC Hammer introduced the Korean star at the American Music Awards as, “My Homeboy PSY!”


Even President Barack Obama is talking about him. Asked on Election Day if he could do the dance, Obama replied: “I think I can do that move,” but then concluded he might “do it privately for Michelle,” the first lady.


PSY was in Thailand to give a free concert Wednesday night organized as a tribute to the country’s revered King Bhumibol Adulyadej, who turns 85 next month. He paid respects to the king at a Bangkok shopping mall, signing his name in an autograph book placed beside a giant poster of the king. He then gave an outdoor press conference, as screaming fans nearby performed the pop star’s dance.


Determined not to be a one-hit wonder, PSY said he plans to release a worldwide album in March with dance moves that he thinks his international fans will like.


“I think I have plenty of dance moves left,” he said, in his trademark sunglasses and dark suit. “But I’m really concerned about the (next) music video.”


“How can I beat ‘Gangnam Style’?” he asked, smiling. “How can I beat 850 million views?”


___


Associated Press writer Thanyarat Doksone contributed to this report.


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Welcome to the Twisted Age of the Twitter Death Threat












Never believe anyone who tells you that the Internet is all nice or all terrible. Just like real life, there are good people and bad ones here. The majority of people behave badly occasionally and decently most of the time. Yes, there are some truly horrible people lurking and behaving in ways consistent to their form, but the thing is, we’re complicated creatures, online and off. So I don’t buy into theories that the Internet is all nice anymore than I believe all commenters are trolls. Still, there is something worrisome going on online, and if you were the Chicken Little type (which none of us here are, obviously), you might be covering your head and hiding from the Twitterverse. It’s this matter of death threats online. 


RELATED: After His Vulgar Assault on Jenny Johnson, Chris Brown Quits Twitter












The most recent example of this, of course, is the recent Chris Brown/Jenny Johnson nastiness. Brown has his share of on- and offline haters, but he has plenty of adamant supporters, too. This became apparent when Johnson, a comedian who’d been on a Twitter crusade of sorts against Brown since his physical attack on Rihanna, after a stream of tweets intended to shame/provoke the singer, finally hit pay-dirt with a response (other than Brown blocking her at one point). Over the weekend, Chris Brown tweeted: “I look old as fuck! I’m only 23,” to which Johnson tweeted, “I know! Being a worthless piece of shit can really age a person.” (That tweet’s been retweeted by Johnson followers more than 7,000 times.)


RELATED: The Internet–Not All It’s Cracked Up to Be


You probably know what happened next, even if you don’t: After a pretty gross back-and-forth that doesn’t make either side look great, Brown deactivated his account. But his followers started to pile on, threatening Johnson with—what else?—death. There is no irony here about the followers of a guy who beat his girlfriend offering up a stream of brutish death threats; it is only sad. 


RELATED: Is Twitter for Girls?


Enter the age of the online death threat. It’s scary, yeah, because it’s a death threat. Humans rarely like being threatened with an end to their basic essence, no matter the delivery method for that announcement. And yet, on Twitter, this becomes such a weird, surreal concept: It’s deeply impersonal (these people don’t even know each other and probably never will; NONE of them know each other, likely), fueled by a false kind of rage spawned by the way the Internet works (one side gets self-righteously mad, another side self-righteously madder, and repeat). Fortunately, in most cases, the threat is also incredibly unlikely to be fulfilled. That doesn’t make it pleasant. One might be prone to try to laugh away the kind of death threats Johnson received, from people she doesn’t know (people who don’t know Chris Brown either), who might not recognize her on the street, who most likely live nowhere near where she does and probably also don’t plan to actually kill her. Yet a death threat is pretty much the ultimate “I hate you,” and it’s worth wondering, when “I hate you” doesn’t serve to deliver the message strongly enough and we start saying “I’m going to kill you”/”you deserve to die,” how far has humanity gone down some sick drain?


RELATED: Only Six Percent of Americans Use Twitter


As David Knowles writes for The Daily in a piece titled “Twitter Terror,” Johnson is hardly the first person to be threatened on Twitter. President Obama, Mitt Romney, Ellen Page, Tom Daley, and Taylor Swift can claim this dubious badge of fame, too. The list goes on. But before the little bird was the death-threat method of the year, death threats would arrive to famous people, politicians, and those in the public eye, particularly controversial figures, as a matter of course—on paper, perhaps by telephone, and in the movies, via the weird scrawlings or puzzle-piece letter constructions of madmen. Of course, there’s no handwriting to decipher on Twitter, there are only assumptions of power and education based on icons and followers, word choice and spelling, what the person says and has said, as well as their affiliations. But again, probably, the people threatening Jenny Johnson shouldn’t scare her (if you’re really going to try to kill someone and are dumb enough to publicize it on Twitter, that’s a clear benefit to your intended victim). If there’s anything to be afraid of, it’s this idea that death threats are this kind of new online norm. I think part of that fear, the fear that this is just a regular thing nowadays, is what subconsciously creates the need in us to assume a such a horrified shock-and-outraged position about such death threats. Knowles quotes digital media expert Jeanette Castillio as calling “the Twitterverse … a very uncivil place.” Is it any more uncivil than anywhere else, though? The Internet hardly created hate, or hate-speak, or bullying. Further, do we only increase the levels of that incivility by freaking out about what a bunch of random people are raging about behind the protection, and often anonymity, of Twitter?


RELATED: Friday’s Top Tweets


As Knowles writes, also, Twitter does have a rule against this sort of thing; people aren’t supposed to “publish or post direct, specific threats of violence against others.” Still, like everything online, there is too much information, and not enough time for comprehensive monitoring. Knowles adds, “A small percentage of violent tweets are investigated by police, but even then Twitter is reluctant to betray what it believes is a sacred duty to protect a user’s privacy.” 


That’s the other thing about online threats: They manage to be so incredibly cowardly, and an utterly ineffectual form of communication—until, suddenly, the media is paying attention to said threats and in some ways legitimizing them. I’m honestly not sure what the media’s role should be in acknowledging tweets of the sort that Brown and Johnson and Brown’s followers and Johnson exchanged. Sometimes it seems like that old “ignoring” tactic your mom taught you could work out to everyone’s benefit—and yet these things are bound to go viral; badly behaving celebrities are something TMZ taught us people want to know about. These things are also, when discussed calmly and rationally, fodder for good conversations about how we live now.


Like a rude comment, a Twitter death threat is a way of hiding in your comfy-safe basement in your comfy-safe boxers and saying really gross things to someone in the hopes that they will get upset. These people are bullying, or hope to bully. Which means we shouldn’t take the bait, a thing far more difficult to do than say. Turning the other cheek was hard in real life, too, and you never know, better safe than sorry. But more important than preventing “actual Twitter murders” (which I dare say and hope will not become the norm), it’s worth paying attention to this ratcheting up of the hate ante as a new kind of communication norm. A cynical person would say we no longer need to touch people, instead, we reach out to them online. We no longer need to talk on the phone, we simply tweet or email or text. We certainly don’t write letters, and we hardly write on paper. Instead we blog and Tumbl and Instagram and Facebook. And so, when we get angry, irrationally or otherwise, we take to those methods of communication to speak out, retaliate, vow revenge. The most worrisome thing about the Twitter death threat, I think, that if it’s just something people do now. I don’t want to be in the Age of the Twitter Death Threat. It makes me pretty nostalgic for the good old days of the handwritten love letter, actually. 


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AAP Recommends Prescribing Emergency Contraception for Teens












In a new policy statement released online on Monday, the American Academy of Pediatrics (AAP) officially recommended that physicians consider prescribing teens emergency contraception in advance. This assertion by the AAP follows on the heels of a new recommendation from the American College of Obstetricians and Gynecologists (ACOG) last week that advocated making birth control pills available to women as an over-the-counter medication.


The AAP stated in a press release published ahead of the policy statement that much of the justification for the organization’s stance lies in the fact that the “United States continues to see substantially higher teen birth rates compared to other developed countries.” Prescribing emergency contraception ahead of time, according to the AAP, may help lower those rates.












What exactly is the AAP recommending?


The AAP is recommending that physicians prescribe emergency contraception, more commonly known as “morning after” pills, to teens, particularly, although not limited to, those that are currently sexually active. Specifically, the AAP is recommending prescribing emergency contraception for those teens who are under the age of 17, as the organization notes that females who are already 17 years of age or older can obtain emergency contraception without a prescription.


What information is the AAP basing its recommendation on?


The AAP has looked at the available research and determined that there is a need for teens to be prescribed the pills in advance in order to try and mitigate the number of unplanned pregnancies, which account for 80 percent of all pregnancies in girls between the ages of 15 and 19. The organization’s policy statement cited the need for teens to be protected against improper use or failure of other contraceptive methods, such as condoms, and also made note of the need to protect teens who may be the victims of sexual assault. The AAP also cited research indicating that teens who are prescribed emergency contraception “in advance of need” are more likely to use it if that need presents itself later, as opposed to teens who must ask for emergency contraception after the fact.


What are the risks involved in prescribing emergency contraception in advance?


The biggest risk factor, according to the AAP’s policy statement, is the fact that emergency contraception can prevent pregnancy (by preventing ovulation), but not sexually transmitted infections. According to a Reuters report, studies have shown that there is no known correlation between a teenager being given access to emergency contraception and them becoming sexually active any earlier.


What has been the reaction to the AAP’s decision to publish this policy statement?


The statement has gotten mostly positive reviews from women’s health advocates, including Susan Wood of the Jacobs Institute of Women’s Health at George Washington University in Washington, who told Reuters on Monday that the AAP’s decision is “significant.” Bill Albert, who is the chief program officer of the National Campaign to Prevent Teen and Unplanned Pregnancy, also praised the decision, telling the Washington Times that his organization “supports wider access to all birth-control products.”


Not everyone is convinced that the AAP’s recommendation is a good thing, however. In that same Washington Times piece, Wendy Wright, who is the vice president for government relations at the Catholic Family and Human Rights Institute, said that “there are too many questions to be answered” before the idea of prescribing emergency contraception to teens should be entertained.


Vanessa Evans is a musician and freelance writer based in Michigan, with a lifelong interest in health and nutrition issues.


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King warns euro risk has grown















Sir Mervyn King: “Mark Carney was the outstanding candidate”



The risk posed by the eurozone has grown, the departing Bank of England governor Sir Mervyn King has warned.


The governor said problems in the eurozone, as well as the US and Asia, lay behind the Bank’s recent pessimism about UK growth prospects in 2013-14.


Speaking to MPs, he defended the Bank’s decision to pass interest earned on the UK gilts it owned back to the Treasury.


He also said the Bank would be in “very good hands” with his recently announced successor as governor, Mark Carney.


Mr Carney was named by Chancellor George Osborne on Monday as his surprise choice for the new Bank of England head.


Currently the governor of the Canadian central bank, Mr Carney will serve for five years and will hold new regulatory powers over banks.


The UK should take pride, Sir Mervyn said, in not only that it could search the world for the best candidate, but that the country was able to produce a “truly outstanding shortlist” from among its own citizens.


‘Slow and protracted’


In evidence to the Treasury Committee, the Bank governor said that Mr Carney – under whom the Bank will be taking on new responsibilities to oversee the health of the country’s banks – faced a difficult task.


“There is a great deal of adjustment to be made in the financial sector, a great deal of adjustment to be made in the economy as a whole,” he said.


“It may be unreasonable to expect anything other than a slow and protracted recovery absent a further fall in the real exchange rate.”


The Bank of England and most City economists say that UK banks must increase their reserves against potential future losses and work their way through problem loans, while the UK economy needs to boost its exports and investment.


The string of difficulties still faced by the UK explained why the Bank chose earlier this month to downgrade the chances of the country experiencing a significant rebound in growth over the coming two years.


“It would take a rather unusual combination of circumstances to see growth of 4% or above in 2013 or 2014,” Sir Mervyn said, adding that the recovery would be much more protracted than has typically been the case after previous recessions.


He confirmed that the Bank’s decision earlier this month to downgrade its forecasts was due to a change of heart amongst the Monetary Policy Committee, rather than any recent economic developments.


“I think there are times where you debate something and you finally decide: ‘Well look, our judgment really has to change now’,” he said.


Global economy doubts


The governor said that the biggest drag on the UK came from the weakness of the global economy.


Continue reading the main story

It is impossible to escape the conclusion that Mr Osborne wants to give a bit of shake to the Bank of England’s culture”



End Quote



Despite recent positive indications from China and from the US housing market highlighted in the Bank’s latest inflation report, the governor expressed doubts.


“I think the staff probably take a more upbeat view on the prospects of the Chinese economy than I would be inclined to,” he said.


He also divulged that private conversations with US colleagues led him to doubt the sustainability of the US recovery.


But he expressed his strongest concerns about the eurozone, claiming that – despite a lull in market anxiety over the euro’s future – the situation on the continent has become worse over the past year.


“The longer the problem goes on, the bigger the adjustment will need to be,” he said, pointing to the continued build-up in debt as southern European governments struggle to regain competitiveness and get their budgets under control.


The governor said that, while the UK economy continued its own adjustment process, the Bank’s ability to stimulate recovery would be limited, although he foresaw that further quantitative easing – purchases by the Bank of government debt – may be warranted.


However, he noted that one of his successor’s most difficult tasks may be to decide when to start raising interest rates or reversing quantitative easing.


“There’s a very difficult policy judgment to be made down the road, first as to when we start tightening monetary policy, and then how rapidly we tighten monetary policy,” he said.


Public accounts


The governor was also questioned by MPs about the Bank’s decision this month to hand back to the Treasury the surplus income that it earns on government debts it holds as a result of its quantitative easing policy.


He admitted that the timing of the announcement could have been handled better – particularly because the Bank’s private knowledge of the agreement had influenced its decision at a committee meeting a few days before the announcement to hold fire on further quantitative easing.


However, he said that the decision did not affect monetary policy or the Bank of England’s independence, although he was concerned it could create the appearance that the Bank was acting under the Treasury’s influence.


The move would not have any meaningful impact on taxpayers, Sir Mervyn said, and all it would achieve was a change in the way that the government reports its borrowing.


“This is about presentation of public accounts, and I do not want to dissuade you from looking into that and raising it with the Treasury, but it is a matter for the Treasury,” he said.


“They are entitled to publish their accounts in the way that they want. And you’re entitled to challenge them about whether those accounts are misleading or not.”


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Rugby-England add flyhalf Burns to squad for All Blacks’ test












LONDON, Nov 27 (Reuters) – England called up uncapped Gloucester flyhalf Freddie Burns on Tuesday to their squad for Saturday’s test against New Zealand in place of the injured Toby Flood.


Flood sustained ligament damage to a big toe during the 16-15 loss to South Africa at Twickenham last Saturday.












Owen Farrell, whose last start was in the first test in South Africa this year, is set to replace Flood in the starting XV against the world champions.


Lock Courtney Lawes, who missed England’s first three tests of the November series because of a knee injury, has also been included in the 23-man squad. Two other locks, Mouritz Botha and Tom Palmer, have been omitted.


After beating Fiji in their opening match, England have lost to Australia and the Springboks and now face a daunting match against the All Blacks who are unbeaten in 20 tests since the start of their victorious World Cup campaign last year.


“For those in Saturday’s squad the message is clear – last week we went toe to toe with the second best team in the world and felt we should have won,” England head coach Stuart Lancaster said in a statement.


“Now we have a chance to take on the number one side in front of a passionate Twickenham crowd, who have been fantastic throughout the Internationals, and it is a challenge we will meet head on.” (Reporting by John Mehaffey; Editing by Ken Ferris)


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ChannelAdvisor says eBay sales up 57 percent early on Cyber Monday












(Reuters) – ChannelAdvisor said client sales on eBay Inc‘s online marketplace jumped 57 percent from a year before early on Cyber Monday.


The sales growth rate was five times higher than during the same period last year, said ChannelAdvisor, which helps merchants sell more on websites including Amazon.com Inc and eBay.com.












Client sales on Amazon.com were up 52 percent during the first part of Cyber Monday, ChannelAdvisor also reported.


(Reporting By Alistair Barr; Editing by Gerald E. McCormick)


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Actor: CBS comedy ‘Two and a Half Men’ is ‘filth’












NEW YORK (AP) — The teenage actor who plays the half in the hit CBS comedy “Two and a Half Men” says it’s “filth” and through a video posted by a Christian church has urged viewers not to watch it.


Nineteen-year-old Angus T. Jones has been on the show since he was 10 but says he doesn’t want to be on it. He says, “Please stop watching it. Please stop filling your head with filth.”












The video was posted by the Forerunner Christian Church in California, where Jones says he went to meet his spiritual needs.


Show producer Warner Bros. Television has no comment. CBS hasn’t responded to a request for comment left Monday.


The show stars Jon Cryer as Jones’ uptight dad and originally featured Charlie Sheen as his hedonistic philandering uncle, but Sheen was replaced by Ashton Kutcher.


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Obama spoke with House Speaker Boehner, others on “fiscal cliff”












WASHINGTON (Reuters) – President Barack Obama spoke with House of Representatives Speaker John Boehner over the weekend on efforts to avert the looming “fiscal cliff” of budget cuts and tax rises that threatens to tip the U.S. economy back into recession.


A White House official said on Monday that Obama also spoke with Senate Majority Leader Harry Reid, a fellow Democrat, and said discussions among staff members continued.












The president met with congressional leaders, including Boehner and Reid, 10 days ago seeking common ground following Obama’s re-election for another four-year term on November 6.


Boehner and fellow Republicans oppose the Democrats’ proposal to raise taxes on the very wealthy as part of arrangements to rein in the enormous U.S. budget deficits.


Starting on January 2, about $ 600 billion worth of tax increases and spending reductions, including $ 109 billion in cuts to domestic and defense programs, will begin to kick in if Congress cannot decide how to replace them with less extreme deficit-reduction measures.


(Reporting by Mark Felsenthal; Editing by David Storey)


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